Season 3 follows the fortunes of a young U-boat crew as they engage in the Battle of the Atlantic, are hunted down by an obsessed Royal Navy Commander (Ray Stevenson) and are sent on a dangerous mission to the Southern Hemisphere. Together they form strong personal alliances under the command of Robert Ehrenberg (Franz Dinda).　　And yet Ehrenberg's thoughts remain in Kiel, where he has developed feelings for Greta (Elisa Schlott). The young mother is married to a man who is seriously injured and suffering from war neurosis. Also in Kiel, Wilhelm Hoffmann's daughter Hannie (Luise Wolfram) is trapped in a loveless marriage to Commander Albrecht Lessing (Florian Panzner), a bitter, emotionally distant man. Hannie suffers under the tight constraints of her status and the social expectations that go with it. When she meets the charming submarine commander Schulz (Pierre Kiwitt), she is playing with fire.　　Meanwhile in the exotic climes of neutral Lisbon where the exiles, spies and criminals of Europe rub shoulders with each other and their enemies, Hagen Forster (Tom Wlaschiha) discovers a lethal plot to steal a fortune in plundered war time gold. These discoveries and aspects of his own history deriving from dark experiences on the Eastern front, lead him to question his own actions and moral path. They also lead him to a shadowy figure caught up in a conspiracy that might change the course of the War - for the better. That man, very much changed by his own shattering experiences, is Klaus Hoffmann (Rick Okon). These two historically based strands come together in an unexpected, thrilling finale.

一批医学院的学生来到圣心医院开始他们的实习生涯，但是从第一天起就发现这里并不是想象中安详宁静的医学圣地，从医生到护士甚至门卫个个不同寻常。内科实习医生杰迪是个聪明而又英俊的年轻人，但是笨拙而又缺乏自信的表现常常惹得医生护士故意欺负他，甚至被叫做“小鹿班比”。特克是杰迪的大学同学，身为外科实习医生的他具有与自信衬的高明医术。伊丽亚特-里德是实习医生中唯一的女性，美丽却神经质，被认为有社交障碍。罗伯特-卡尔索医生和佩里-考克斯医生是圣心医院的主要医师，两人也是天生的冤家对头。　　从实习医生成为正式医生的过程充满了艰辛和痛苦，当然也有令人喜悦的胜利，他们在病房中接触到各式各样的病人、第一次直接面对病人的死亡、时不时还被卷入医生间的竞争。他们的爱情也和工作一样丰富多彩。杰迪和伊丽亚特彼此吸引，两人却分分合合在友情和爱情之间摇摆；特克追上了美丽的护士卡拉，但卡拉强烈的控制欲令特克感到一丝恐惧；离婚的考克斯医生暗恋着卡拉，但是从来无法抵抗前妻乔丹的诱惑。　　短短一年的实习生涯中，杰迪们从菜鸟渐渐成长为合格的医生，也从病人的悲欢离合中领悟到生命、爱情和生活的真谛。当他们以医生的身份重新回到圣心医院时，一部完全不同的故事再次开幕。(一平文)

The 4400 tells the stories of 4,400 alien abductees after they are returned to earth. In the words of the executive producers, these are stories of people dealing with traumatic changes, driven by the mystery of what happened and why. Some of them have been affected in mysterious ways, and some will have certain abilities, both good and bad, so part of the drama will be watching them adjust to these changes within themselves.　　The series kicks off with a ball of light sailing toward Earth, but rather than the expected catastrophic event, thousands of returned abductees are left with no memory of their otherworldly experiences. Each has been gone anywhere from a few months to several decades but hasn't aged a day.　　在海滩事件——4400人被未来世界的人带走又送回来，披露后一年，世界发生了巨大的变化。经过一段紧张的医疗观测后，Tom回到了国家技术援助中心，由于能力有限，被派做文书工作。他最终保护了儿子，使其免受一个类似的政府研究，而且也为有希望重新过上正常的生活而激动。在事业方面，他也渴望再次同Diana合作，重新回到这个领域。Diana，在同一连串无能的搭档合作之后，最终找到毁掉公文让Tom重回岗位的办法，在此期间，她还正式收养了Maia。　　其间，Richard，Lily，和他们的孩子——一个六个月大，不同寻常的孩子，仍然住在远离Jordan Collier的山间小屋里，过着粗茶淡饭的日子。Collier已经关掉了Arcadia Estates ，还有他的住宅，为这4400人建起了避难所，同时准备开“4400人中心”，在这儿，其他人可以深入到这4400人当中，自己去发掘4400人（的奥秘）。Collier在接触Lily的腹部之后，出现了有害的反应，Shawn治愈了他，之后他们就发展出亲密的父子关系。Collier成了Shawn的监护人，并利用他医治4400人中心的重要赞助人。　　世人对4400人甚感好奇，于是关于他们的神秘能力的流言四处传播，公众态度分为两种，一种是包容他们，一种是畏惧他们。当4400人努力重新开始他们“被打断的生活”时，每个人都会在即将发生的事件中扮演关键角色…那些决定人类命运的事件。